MicroRNA-22 Regulates the Pro-inflammatory Responses and M1 Polarization of Macrophages by Targeting GLUT1 and 4-1BBL

Many microRNAs (miRNAs) are selectively expressed in mammalian immune cells and have been linked to responses host defense autoimmune disease. In macrophages, miRNAs regulate cell metabolism by repressing the expression of genes such as transcription factors, enzymes, metabolism-related molecules, well that impact inflammatory phenotype determination. Previous studies showed miR-22 plays a role variety biological processes, cancer growth, survival, expansion. CD4 + T bowel disease patients, is upregulated regulates inflammasome-mediated responses. However, it has not yet determined how contributes activation innate cells. this study, we identified mechanism toll-like receptors- (TLR-) dependent induction downstream signaling pathway linking macrophage polarization. MiR-22 induced via TLR-signaling, which Slc2a1 (glucose transporter 1 Glut1) Tnfsf9 (tumor necrosis factor 9, 4-1BB ligand, 4-1BBL) mRNAs contribute sustained polarization macrophages. Our observations support further efforts explore potential therapeutic strategy using for modulation excessive treatment diseases.